Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral
Identifieur interne : 001781 ( Main/Exploration ); précédent : 001780; suivant : 001782Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral
Auteurs : Girish J. Kotwal [Afrique du Sud] ; Jennifer N. Kaczmarek [Afrique du Sud] ; Steven Leivers [Afrique du Sud] ; Yohannes T. Ghebremariam [Afrique du Sud] ; Amod P. Kulkarni [Afrique du Sud] ; Gabriele Bauer [Afrique du Sud] ; Corena De Beer [Allemagne] ; Wolfgang Preiser [Allemagne] ; Abdu Rahman Mohamed [Afrique du Sud]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2005-11.
English descriptors
- Teeft :
- Acidic plant, Active ingredient, Antiviral, Antiviral activity, Antiviral drugs, Antiviral effects, Assay, Bioactive, Bioactive agent, Bioactive molecules, Cape town, Cell lines, Crude plant, Cutoff filter, Health sciences, Human immunodeficiency virus, Influenza virus, Kotwal, Life cycle, Liquid chromatography, Medical virology, Plaque formation, Significant effect, Toxicity, Trifollium species, Vaccinia, Vaccinia virus, Viral, Viral attachment, Viral infections, Viral infectivity, Viral loads, Virus, Virus noninfectious, Virus particles, West nile virus, York academy.
Abstract
Enveloped animal viruses such as human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, human papillomavirus, Marburg, and influenza are major public health concerns around the world. The prohibitive cost of antiretroviral (ARV) drugs for most HIV‐infected patients in sub‐Saharan Africa and the serious side effects in those who have access to ARV drugs make a compelling case for the study of complementary and alternative therapies. Such therapies should have scientifically proved antiviral activity and minimal toxic effects. A plant extract, Secomet‐V, with an anecdotal indication in humans for promise as an anti‐HIV treatment, was investigated. Using a previously described attenuated vaccinia virus vGK5, we established the antiviral activity of Secomet‐V. Chemical analysis showed that it has an acidic pH, nontoxic traces of iron (<10 ppm), and almost undetectable levels of arsenic (<1.0 ppm). The color varies from colorless to pale yellow to dark brown. The active agent is heat stable at least up to sterilizing temperature of 121°C. The crude plant extract is a mixture of several small molecules separable by high‐pressure liquid chromatography. The HIV viral loads were significantly reduced over several months in a few patients monitored after treatment with Secomet‐V. Secomet‐V was also found to have antiviral activity against the SARS virus but not against the West Nile virus. Secomet‐V, therefore, is a broad‐spectrum antiviral, which possibly works by neutralizing viral infectivity, resulting in the prevention of viral attachment.
Url:
DOI: 10.1196/annals.1352.014
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000391
- to stream Istex, to step Curation: 000358
- to stream Istex, to step Checkpoint: 000266
- to stream Main, to step Merge: 001791
- to stream Main, to step Curation: 001781
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral</title><author><name sortKey="Kotwal, Girish J" sort="Kotwal, Girish J" uniqKey="Kotwal G" first="Girish J." last="Kotwal">Girish J. Kotwal</name></author><author><name sortKey="Kaczmarek, Jennifer N" sort="Kaczmarek, Jennifer N" uniqKey="Kaczmarek J" first="Jennifer N." last="Kaczmarek">Jennifer N. Kaczmarek</name></author><author><name sortKey="Leivers, Steven" sort="Leivers, Steven" uniqKey="Leivers S" first="Steven" last="Leivers">Steven Leivers</name></author><author><name sortKey="Ghebremariam, Yohannes T" sort="Ghebremariam, Yohannes T" uniqKey="Ghebremariam Y" first="Yohannes T." last="Ghebremariam">Yohannes T. Ghebremariam</name></author><author><name sortKey="Kulkarni, Amod P" sort="Kulkarni, Amod P" uniqKey="Kulkarni A" first="Amod P." last="Kulkarni">Amod P. Kulkarni</name></author><author><name sortKey="Bauer, Gabriele" sort="Bauer, Gabriele" uniqKey="Bauer G" first="Gabriele" last="Bauer">Gabriele Bauer</name></author><author><name sortKey="De Beer, Corena" sort="De Beer, Corena" uniqKey="De Beer C" first="Corena" last="De Beer">Corena De Beer</name></author><author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name></author><author><name sortKey="Mohamed, Abdu Rahman" sort="Mohamed, Abdu Rahman" uniqKey="Mohamed A" first="Abdu Rahman" last="Mohamed">Abdu Rahman Mohamed</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:910558151BB0B6F28C15332032D15371ABD12055</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1196/annals.1352.014</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-9JZBVTVZ-L/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000391</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000391</idno><idno type="wicri:Area/Istex/Curation">000358</idno><idno type="wicri:Area/Istex/Checkpoint">000266</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000266</idno><idno type="wicri:doubleKey">0077-8923:2005:Kotwal G:anti:hiv:anti</idno><idno type="wicri:Area/Main/Merge">001791</idno><idno type="wicri:Area/Main/Curation">001781</idno><idno type="wicri:Area/Main/Exploration">001781</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral</title><author><name sortKey="Kotwal, Girish J" sort="Kotwal, Girish J" uniqKey="Kotwal G" first="Girish J." last="Kotwal">Girish J. Kotwal</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Kaczmarek, Jennifer N" sort="Kaczmarek, Jennifer N" uniqKey="Kaczmarek J" first="Jennifer N." last="Kaczmarek">Jennifer N. Kaczmarek</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Leivers, Steven" sort="Leivers, Steven" uniqKey="Leivers S" first="Steven" last="Leivers">Steven Leivers</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Quantum House, Technopark, Stellenbosch, 6090, Uniedal</wicri:regionArea><wicri:noRegion>Uniedal</wicri:noRegion></affiliation></author><author><name sortKey="Ghebremariam, Yohannes T" sort="Ghebremariam, Yohannes T" uniqKey="Ghebremariam Y" first="Yohannes T." last="Ghebremariam">Yohannes T. Ghebremariam</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Kulkarni, Amod P" sort="Kulkarni, Amod P" uniqKey="Kulkarni A" first="Amod P." last="Kulkarni">Amod P. Kulkarni</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Bauer, Gabriele" sort="Bauer, Gabriele" uniqKey="Bauer G" first="Gabriele" last="Bauer">Gabriele Bauer</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Medical Virology, NHLS, Tygerberg Business Unit, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="De Beer, Corena" sort="De Beer, Corena" uniqKey="De Beer C" first="Corena" last="De Beer">Corena De Beer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, J.W. Goethe‐Universitat, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, J.W. Goethe‐Universitat, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Mohamed, Abdu Rahman" sort="Mohamed, Abdu Rahman" uniqKey="Mohamed A" first="Abdu Rahman" last="Mohamed">Abdu Rahman Mohamed</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of the New York Academy of Sciences</title><title level="j" type="alt">ANNALS OF NEW YORK ACADEMY SCIENCES</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><biblScope unit="vol">1056</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="293">293</biblScope><biblScope unit="page" to="302">302</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2005-11">2005-11</date></imprint><idno type="ISSN">0077-8923</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acidic plant</term><term>Active ingredient</term><term>Antiviral</term><term>Antiviral activity</term><term>Antiviral drugs</term><term>Antiviral effects</term><term>Assay</term><term>Bioactive</term><term>Bioactive agent</term><term>Bioactive molecules</term><term>Cape town</term><term>Cell lines</term><term>Crude plant</term><term>Cutoff filter</term><term>Health sciences</term><term>Human immunodeficiency virus</term><term>Influenza virus</term><term>Kotwal</term><term>Life cycle</term><term>Liquid chromatography</term><term>Medical virology</term><term>Plaque formation</term><term>Significant effect</term><term>Toxicity</term><term>Trifollium species</term><term>Vaccinia</term><term>Vaccinia virus</term><term>Viral</term><term>Viral attachment</term><term>Viral infections</term><term>Viral infectivity</term><term>Viral loads</term><term>Virus</term><term>Virus noninfectious</term><term>Virus particles</term><term>West nile virus</term><term>York academy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Enveloped animal viruses such as human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus, human papillomavirus, Marburg, and influenza are major public health concerns around the world. The prohibitive cost of antiretroviral (ARV) drugs for most HIV‐infected patients in sub‐Saharan Africa and the serious side effects in those who have access to ARV drugs make a compelling case for the study of complementary and alternative therapies. Such therapies should have scientifically proved antiviral activity and minimal toxic effects. A plant extract, Secomet‐V, with an anecdotal indication in humans for promise as an anti‐HIV treatment, was investigated. Using a previously described attenuated vaccinia virus vGK5, we established the antiviral activity of Secomet‐V. Chemical analysis showed that it has an acidic pH, nontoxic traces of iron (<10 ppm), and almost undetectable levels of arsenic (<1.0 ppm). The color varies from colorless to pale yellow to dark brown. The active agent is heat stable at least up to sterilizing temperature of 121°C. The crude plant extract is a mixture of several small molecules separable by high‐pressure liquid chromatography. The HIV viral loads were significantly reduced over several months in a few patients monitored after treatment with Secomet‐V. Secomet‐V was also found to have antiviral activity against the SARS virus but not against the West Nile virus. Secomet‐V, therefore, is a broad‐spectrum antiviral, which possibly works by neutralizing viral infectivity, resulting in the prevention of viral attachment.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Allemagne</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li></settlement></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Kotwal, Girish J" sort="Kotwal, Girish J" uniqKey="Kotwal G" first="Girish J." last="Kotwal">Girish J. Kotwal</name></noRegion><name sortKey="Bauer, Gabriele" sort="Bauer, Gabriele" uniqKey="Bauer G" first="Gabriele" last="Bauer">Gabriele Bauer</name><name sortKey="Ghebremariam, Yohannes T" sort="Ghebremariam, Yohannes T" uniqKey="Ghebremariam Y" first="Yohannes T." last="Ghebremariam">Yohannes T. Ghebremariam</name><name sortKey="Kaczmarek, Jennifer N" sort="Kaczmarek, Jennifer N" uniqKey="Kaczmarek J" first="Jennifer N." last="Kaczmarek">Jennifer N. Kaczmarek</name><name sortKey="Kulkarni, Amod P" sort="Kulkarni, Amod P" uniqKey="Kulkarni A" first="Amod P." last="Kulkarni">Amod P. Kulkarni</name><name sortKey="Leivers, Steven" sort="Leivers, Steven" uniqKey="Leivers S" first="Steven" last="Leivers">Steven Leivers</name><name sortKey="Mohamed, Abdu Rahman" sort="Mohamed, Abdu Rahman" uniqKey="Mohamed A" first="Abdu Rahman" last="Mohamed">Abdu Rahman Mohamed</name></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="De Beer, Corena" sort="De Beer, Corena" uniqKey="De Beer C" first="Corena" last="De Beer">Corena De Beer</name></region><name sortKey="Preiser, Wolfgang" sort="Preiser, Wolfgang" uniqKey="Preiser W" first="Wolfgang" last="Preiser">Wolfgang Preiser</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001781 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001781 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:910558151BB0B6F28C15332032D15371ABD12055
|texte= Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral
}}
| This area was generated with Dilib version V0.6.33. |  |